Rafael van der Vaart scored and was then sent off as Tottenham beat FC Twente 4-1 at White Hart Lane in the Champions League.
Internazionale destroyed hapless Werder Bremen 4-0 in their Champions League clash at the Giuseppe Meazza.
Lyon maintained their 100 per cent record in Champions League Group B with a 3-1 win over Hapoel Tel Aviv in Israel.
Second half goals from Jefferson Farfan and Klaas-Jan Huntelaar fired Schalke to a 2-0 victory against Benfica in the Champions League.
Substitute Javier Hernandez struck the only goal of the game with five minutes to play as Manchester United beat Valencia 1-0.
Rangers won their first Champions League match in three years courtesy of a tense 1-0 victory over Turkish champions Bursaspor at Ibrox.
A brilliant performance from Dame N’Doye inspired FC Copenhagen to a 2-0 win over Panathinaikos at the OACA Spiros Louis Stadium in Athens.
A disciplined Rubin Kazan side made life tough for Barcelona and forced a 1-1 draw in their Champions League clash in Russia.